High Frequency of Class I and II Integrons and the Presence of aadA2 and dfrA12 Gene Cassettes in the Clinical Isolates of Acinetobacter baumannii from Shiraz, Southwest of Iran

Background: Acinetobacter baumannii is a global concern that causes healthcare-associated infections due to multidrug resistance against commercially available antimicrobial agents. Objectives: The present study was conducted determine the susceptibility of A. isolates from clinical specimens in Shiraz, Iran. In addition, possible relationship patterns with presence integrons and related gene cassettes investigated. Methods: were collected, their various antibiotics tested using Kirby-Bauer disk diffusion method. Moreover, molecular analysis performed detect OXA-51-like gene, as well class I, II, III integrons, associated cassettes. Results: majority resistant imipenem (99.4%), piperacillin (98.2%), gentamycin meropenem (97.7%), ceftazidime (95.4%), amikacin trimethoprim-sulfamethoxazole (90.8%). All strains showed antibiotics. distribution genes revealed 90.2, 72.4, 12.1% carried intI1, intI2, intI3 genes, respectively. two types prevalent cassettes, including aad dfr, detected 1 integron-carrying strains. Conclusions: current high prevalence harboring our investigated medical center, which may indicate events. different cassette arrays highlight remarkable role geographical issues disseminating multidrug-resistant (MDR) isolates. This could be attributed distinct therapeutic interventions areas. results demonstrate necessity continuous surveillance prevent among